Encoding an Decoding Function in the Genome. Friday February 4th to Friday February 11th, 2022
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This meeting brings together researchers interested in approaches that systematically modify and perturb genomes in order
- [DECODE] to understand the function of the target loci in terms of gene expression and regulation;
- [ENCODE] to modify the function of the target loci to change its expression and regulation for specific goals.
The invitees collectively champion modern -omic approaches that often include precise genome editing (eg CRISPR/Cas9) applied to populations in a high-throughput manner using different strategies (eg lentiviral infections or robotic delivery), tracked in different ways (eg competitive growth assays versus single cell droplet encapsulation), and profiled with -omic and microscopy technologies. Such systematic screens are central to exploring
- to build codebooks describing interactions between DNA, RNA, protein, and genome struture;
- to decipher the multivariate biology of higher order genetic and biochemical interactions;
- to understand the interconnected relationships in systems from ecology, health, and disease;
- to efficiently optimize systems in the context of synthetic biology.